NanoDiaRA, a consortium of 15 partners, 7 of them situated in Switzerland, is looking forward to welcoming interested people from research and development, industry and society and to show you new approaches of in-vitro and in-vivo technologies.

Micro- and nanotechnology based novel diagnostic tools for easy and early detection of disease progression and for evaluating the efficacy of therapeutic interventions become more and more necessary for complex diseases like e.g. Rheumatoid Arthritis (RA) and Osteoarthritis (OA). Using modified superparamagnetic nanoparticles (SPION) detection, disease progression can be examined by using (A) bioassays (ex-vivo application) and/or (B) imaging methods like MRI (in-vivo detection). In both cases, multiple functionalized single nanoparticles have to be developed. These particles have the ability to specifically enter/attach to cells or to enzymes in serous fluids or organelles in living cells to separate and identify low-abundance biomarkers.

As existing diagnostic methods often do not permit an early definite diagnosis, novel techniques targeting to the detection of molecular events with higher sensitivity/specificity will be developed. New approaches and results, which have enabled to start the FP7-funded F&E Project NanoDiaRA in February 2010, will be presented at this seminar. The project is driven by the high clinical need to identify early arthritis and then segment RA and OA patients into progressors/responders or non-progressors/-responders to various treatment options.

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